It’s been long established that our working memory, which allows us to temporarily hold and use information, such as remembering a phone number or a shopping list, is largely driven by the brain’s prefrontal cortex. However, new research finds that the part of the brain used in visual processing plays a much more critical role in working memory than previously thought. 

Marcela Maus, MD, PhD, director of the Cellular Immunotherapy Program and the Paula J. O'Keeffe Endowed Chair of the Mass General Cancer Center, is senior author and Stefanie Bailey, PhD, Hana Takei, and Giulia Escobar, PhD of the Krantz Family Center for Cancer Research at Massachusetts General Hospital are co-lead authors of a paper published in Science Translational Medicine, “IFN-g-resistant CD28 CAR-T cells demonstrate increased survival, efficacy, and durability in multiple murine tumor models.”